Adverse effects of subconjunctival 5 fluorouracil in the eye

ABSTRACT

This study evaluated the use of subconjunctival 5-FU in the animal model. Fourteen pigmented rabbits were used, ten of them for therapy and four as controls. The therapy groups was injected subconjunctivaly with 3 mg of 5-FU daily for 14 days and the controls were injected with normal saline. The results were evaluated clinically and histopathologically Sub-conjunctival 5-FU was complicated by squamous metaplasia and keratinization of the conjunctival epithelium, and the absence of goblet cells. These changes were reversible after termination of therapy. In addition, the superior rectus muscle degeneration and fibrosis were marked in the therapy group and were irreversible