Comparative enzymatic and histological studies on albino rat organs treated with yeast spp isolated of air spore in Zagazig

ABSTRACT

The prevalence of yeast spores in the atmosphere of Zagazig City, was investigated over a period of one year. The total count showed seasonal periodicity. Eighteen spp. of yeasts belonging to 10 genera were recovered and identified. Three spp. were chosen in this study as a typical components of air spora due to their host toxic effect [C and ida albicans, C. guilliermondii and C. parapsilosis]. Cell free supernatants from cultures were injected to some rat groups 0.5 ml/BW daily for one week. The treated organs were examined showing enzymatic changes. The level of GOT and GPT under the effect of the three yeast spp. Showed a marked decrease in liver and kidney while there was an increase in the brain tissue. The alkaline phosphatase and LDH concentration were increased significantly in the liver, kidney and brain in the first yeast spp. The results correlated with toxic potency as they cause destructive changes in hepatic, renal tissue as well as in the nervous tissue. Microscopically, the organs injected by C. albicans were the most effected