Evaluation of maternal serum C-reactive protein level: as test for prediction of chrioamniotitis in cases of premature rupture of membranes

ABSTRACT

Serum level of c-reactive protein [CRP] were measured prospectively using immunoradiometric assay in 14 patients with premature rupture of membranes [PROM] < 6 hours, 12 women with PROM > 24 hours and less than 48 hours and 10 women in labour with intact membranes as control group, we evaluate the C-reactive protein [CRP] for its ability to predict the occurrence of clinical chorioamnionitis. Our result showed that their was a statistically significant higher incidence of cases with CRP rise [> 1.87 mg/dl] among cases with PROM than in control cases [P < 0.01]. It was also found that there is a statistically significant higher incidence of clinical chorioamnonitis among cases which showed rise of maternal serum CRP [P < 0.01]. Moreover, the result demonstrates that CRP is more sensitive test and less specific than white blood cell count in identifying clinical chorioamnonitis