Effect of low-dose triphasic and biphasic oral contraceptive preparation of alpha-fetoprotein[AFP] and pregnancy B1 glycoprotein [SP1]

ABSTRACT

50 women in productive age was included in this study with aim of comparative study on alpha-fetoprotein and pregnancy specific B[1]-glycoprotein level in two group of women receiving two types of oral contraceptive pills, [Nordette and Trivolar] after six month of pill intake. The serum is withdraw from women after overnight fasting and allowed to clot at 37°C, the retracted clot is removed and centrifugation at room temperature, the serum was stored in deep freez at-4°C until use. Enzyme-linked immuno-sorbent Assay [ELISA] used for determination of AFP and SP[1] Enzgnast AFP Hoechest [1982] and Enzognast SP[1] Hoechest [1982] and both are measured photometrically at wave length [492 nm]. The serum AFP after six month of pill intake in Nordette group was 4.92 +/- 1.08 Iu/ml] these level was significantly increased. [P < 0.001] as compared to control group, [3.02 +/- 1.06 Iu/ml]. But in Trivolar group, the serum AFP was [3.11 +/- 1.35 Iu/m], statistically significant decrease if it is compared to Nordette group [P < 0.001] and insignificant if it is compared to control group. The serum level of SP[1] in study group [Nordett and Triovlar] was 0.62 +/- 2.8 and 0.56 +/- 0.26 ug/l respectively this figures was insignificant if it is compared to control group