Synthesis of polyfunctionally substituted pyrimidines and pyridines condensed with other heterocyclic systems
Alexandria Journal of Pharmaceutical Sciences. 1993; 7 (3): 223-225
em Inglês
| IMEMR
| ID: emr-26940
ABSTRACT
Treatment of benzoylacetonitrile with anisaldehyde afforded alpha- cyanochalcone [I], which on reaction with malononitrile yielded 2-amino-3,5-dicyano-4-[p-methoxyphenyl]-6-phenyl-4H-pyran [III]. Compound III underwent Michael reaction with aniline derivatives to give 3,5-dicyano-4-[p-methoxyphenyl]-6-phenyl-2-[p-substituted arylamino] pyridine derivatives Va-d. Reaction of III with hydroxylamine hydrochloride, acetic anhydride, malononitrile and benzoylisothiocyanate gave, respectively, compounds IX, X, XI and XIV
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Piridinas
/
Compostos Heterocíclicos
Idioma:
Inglês
Revista:
Alex. J. Pharm. Sci.
Ano de publicação:
1993
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