Immunohistochemical determination of hormone-receptors in juvenile nasopharyngeal angiofibroma

ABSTRACT

Immunoperoxidase technique was used for detection of testosterone and oestrogen receptors in tissue sections prepared from 5 nasopharyngeal angiofibromas excised from 5 juvenile boys. None were positive for oestrogen receptors. Testosterone receptors were present in the covering epithelium in all cases and in the tumour tissue only in three. These findings support the view that juvenile nasopharyngeal angiofibroma is an androgen dependent tumour and may explain the variability of the response to oestorgen therapy