Synthesis and pharmacological screening of some new phenothiazine derivatives

ABSTRACT

Some of phenothiazine derivatives; namely, 10H- phenothiazine-2-carboxylic acid 1- or 2-phenylcarbamoyl ethyl ester [3] and [4] as well as 2-[1,5-diphenyl-4,5-dihydro-1H-pyrazol-3-yl]-10H-phenothiazine and 2-[5-[4-chlorophenyl]-4,5-dihydroisoxazol-3-yl]-10H-phenothiazine derivatives 5 and 6, were synthesized. Compounds 4 showed interesting levels of analgesic and tranquilizing activities comparable with that of paracetamol and chlorpromazine, respectively