Experimental association of infection by salmonella and schistosoma mansoni in Swiss Albino mice

ABSTRACT

Sixty swiss males albino mice from the same breed, were used in this study. They were classified into four groups [I] normal non-infected control group [10 mice][II] control group infected by Salmonella typimurium organism [10 mice][III] control group infested by Sch. mansoni [20 mice] and [IV] a study group infected by both Sch. mansoni and Salmonella typimurium [20 mice] The relation between schistosomiasis and salmonella organism was evaluated by egg-count per gram stool and per gram liver tissue and by studying the worm load by worm perfusion method. The relation was also evaluated by a histopathological study for the liver, spleen and intestine and by a bacteriological study including culture of the perfused worms, liver and spleen. The study demonstrated 0.99% reduction of egg-count per gram stool and 0.61% reduction of egg-count per gram liver tissue in the group [IV] compared to the third one. Histo pathological study revealed reduction of bilharzial granulomas in the liver of group [IV] compared to the third group. Regarding the bacteriological study, the most important result was the presence of salmonella growth in 60% of cultures of perfused worms from group [IV]