Acridines as a new class of antiviral agents against human immunodeficiency virus [HIV-1]

9-[4-substituted sulfamoylphenyl] aminoacridin-4-yl-[N-[4-substituted sulfamoylphenyl]] carboxamide [11, 14]; 1-chloro-9-[4-substituted sulfamoylphenyl] aminoacridine-4-yl [N-[4-substituted sulfamoylphenyl]] carboxamide [12, 15], and 3-chloro-9-[4-substituted sulfamoylphenyl] aminoacridine-5-yl-[N-[4-substituted sulfamoylphenyl]] carboxamide [13, 16] were synthesized. Representative compounds were tested for antiviral [anti-HIV-1] activities. One compound [14g] showed significant anti-HIV-1 activity