In-vitro and in-vivo evaluation of cinnarizine solid dispersions
Egyptian Journal of Pharmaceutical Sciences. 1993; 34 (4-6): 669-682
em Inglês
| IMEMR
| ID: emr-27906
ABSTRACT
To solve the problem of cinnarizine dissolution, its solid dispersions with certain amino acids, aspartame, gentisic acid ethanolamide [GAEA], and Eudragit E100 were prepared in different ratios. The prepared solid dispersions were subjected to dissolution rate studies in comparison to plain cinnarizine as well as the drug treated in the same way without additives. Effect of aging on drug dissolution was also investigated. Selected cinnarizine coprecipitates containing 2 1 w/w Eudragit E100 [FII], 1 5 M aspartame [FIII] and 1 3M Dl-phenylalanine [FIV] were subjected to in vivo bioavailability testing compared to plain cinnarizine [FI]. HPLC method was used to quantitate cinnarizine in rabbits' serum
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Farmacologia
/
Aminoácidos
Idioma:
Inglês
Revista:
Egypt. J. Pharm. Sci.
Ano de publicação:
1993
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