Cytogenetic study in idiopathic infertile males

ABSTRACT

Sex chromatin investigations, including X- chromatin and Y-chromatin, was carried out on one hundred idiopathic infertile males with marked oligospermia or azoospermia. Seven cases [7%] were X-chromatin positive, 18% of the cases had aberrant Y-body [10% big Y, 7% small Y and 1% double Y]. Such Y-chromosome abnormalities were frequent among azoospermic than oligospermic males. Chromosomal analysis of patients with positive X-chromatin and/or abnormalities of the chromosome showed chromosomal abnormalities in the seven azoospermic cases [7%] which were X-chromatin positive. These chromosomal abnormalities varieties of mosaic Klinefelter. Six patients [6%] were 46,XY/47,XXY mosaic and one patient [1%] was 46,XY/47,XXY/48,XXYY mosaic. In conclusion, chromosome analysis as well as sex-chromatin analysis is necessary in the investigation of male infertility