Lipoprotein pattern with chronic hemodialysis

ABSTRACT

The study was conducted on 10 adult male patients with chronic renal failure on regular hemodialysis as well as 10 normal healthy control subjects with matching age and sex. All patients were subjected to complete clinical and laboratory investigation to diagnose renal failure and exclude other diseases that alter lipid metabolism. All patients and controls were subjected to the estimation of urea and creatinine in serum, and estimation of serum levels of triglycerides, total cholesterol, HDL-c, LDL-c, VLDL-c and apolipoprotein B. Results of this study showed that chronic renal failure patients on regular hemodialysis had disturbed lipid metabolism. They had their serum cholesterol within normal levels. The serum levels of their triglycerides [TG], low-density lipoprotein [LDL], very low-density lipoprotein [VLDL] and apolipoprotein-B [Apolipo-B] were higher than normal control cases, while their high density lipoproteins [HDL] serum levels were below that of the normal control cases. Hemodialysis appears to modify lipoprotein abnormalities observed in patients with chronic renal failure undergoing maintenance hemodialysis as only serum levels of low density lipoproteins [LDL] showed return to normal levels by continuity of the dialysis. It was concluded that these abnormalities in lipoprotein composition may be responsible for increasing risk for cardiovascular atheromatous disease in regular hemodialysis patients