Myelofibrosis in active vitamin D deficiency rachitic children and the effect on hematopoiesis

ABSTRACT

There was a significant increase in reticulin in bone marrow among rachitic children with anemia [50%] and highly significant increase in reticulin among rachitic children with anemia and hepatosplenomegaly [90%], compared with controls and rachitic children without anemia. As regards blood picture, there was a significant increase in immature granulocytes and immature erythrocytes among rachitic children with anemia and highly significant increase among rachitic children with anemia and hepatosplenomegaly, compared with controls. The results of total leucocytic count, platelet count showed insignificant statistical difference among rachitic children compared with control group. There was a proportional increase between the degree of reticulin and alkaline phosphatase activity. The higher the reticulin grade, the higher the alkaline phosphatase activity. However, a reciprocal correlation between reticulin and hemoglobin has been noted. The higher reticulin grading, the lower hemoglobin concentration. Lastly, a relation between reticulin grading and the size of the liver and spleen has been observed. The higher reticulin grade, the larger the size of the liver and spleen. It could be concluded that active vitamin D deficiency rickets is associated with anemia and secondary myelofibrosis and may be accompanied with myeloid metaplasia