Biochemical and histopathological changes as markers of alcoholism in atbino rats

ABSTRACT

Fourty mature albino rats of buth sexes were divided into four equal groups. Three groups received doses equivalent to 1/20, 1/10 and 1/5 L D50 of ethanol, six days/week orally for eight weeks. The remaining group served as a control. Serum and vitreous levels of Na, K, uric acid, ALT, AST and GGT were measured. Most of the obtained results were significantly different from those of the control group in such a way that would help in detecting alcohol abuse especially the GGT levels. Histopathological findings in the internal organs of rats [liver, kidneys, lungs, spleen and testes] revealed changes of variable degree of severity, but are not pathognomonic for alcohol abuse