Histological and histochemical studies on the effect of experimentally induced hypothyroidism by carbimazole on the kidney of the female albino rat

ABSTRACT

The present investigation comprised the study of the effect of experimentally induced hypothyroidism on the kidney of the female albino rats, with an average weight 200 g. Experimentally induced hypothyroidism was performed by giving 12 animals a daily oral dose of 2.4 mg carbimazole for 3 and 4 months, respectively. 6 age-matched animals were used as controls. The kidneys of the experimentally induced hypothyroid animals presented a significant decrease in the mean value of their weights, as well as marked histological changes in the renal corpuscles, proximal convoluted tubules, and the interstitial tissue of the kidney. These changes were more marked in animals with an experimentally induced hypothyroidism for 4 months. The histochemical changes in the kidney were more marked in animals with an experimentally induced hypothyroidism for 4 months. The succinic dehydrogenase enzyme activity was markedly increased in the lining cells of most of the proximal convoluted tubules. Moreover, the alkaline phosphatase enzyme activity was increased in the lining cells of most of the proximal convoluted tubules, especially those in the inner cortical region. Some proximal convoluted tubules in the outer cortical region showed a decreased alkaline phosphatase enzyme activity in their lining cells