Histological and histochemical studies on the effect of experimental unilateral complete ligation of the left ureter on both kidneys of the albino rat

ABSTRACT

This study was carried out on 50 male albino rats, with an average weight 200 g. They were divided into 2 equal groups. The first group was subjected to sham operation and served as a control group. Whereas, the second group was subjected to experimental complete ligation of the left ureter. Morphometric, histological and histochemical studies in both the obstructed and contralateral kidneys were performed at 1, 2, 7, 14 and 28 days after ureteric obstruction. From the results obtained, it could be concluded that experimental complete ureteric obstruction affected both kidneys. The obstructed kidney showed structural and functional enzymatic impairments with persistence of some intact renal tubules at 7 days following ureteric obstruction. By the 14th day, the obstructed kidney showed extensive tubular atrophy, together with an intense interstitial cellular infiltration and much increased collagenous fibers. On the other hand, the contralateral kidney revealed compensatory renal growth and increased enzymatic activity that could reflect structural and functional workload adaptation