Experimental and clinical evaluation of new hepatobiliary imaging agent Tc99m bromide

ABSTRACT

To optimize the hepatobiliary imaging techniques by radionuclides, kit procedure for the preparation of Tc-99m labelled BROMIDA [2, 4, 6 trimethyl bromo- IDA] is described. Different parameters effecting the yield [%] of the final product were evaluated. The maximum labelling efficiency of radiopharmaceutical recorded was 99%. The amount of free TCCH and hydrolysed fraction was less than 1%. The radiochemical purity checked by T.L.C method showed more than 96% labelled complex upto 6 hours. In vivo distribution studies demonstrated excellent uptake of Tc-99m BROMIDA by the hepatocytes and no artifacts were seen on scintigraphic images