Comparative study of bioavailabilities of three formulations of cotrimoxazole tablets

ABSTRACT

Bioavailablities of three brands of Cotrimoxazole tablets, from local and international firms, were studied in eight healthy human volunteers by double blind cross - over design. Bioavailability of Sulphamethoxazole was determined from area under the curve of plasma concentrations versus time, while that of Trimethoprim was determined by measuring the cumulative amount of unchanged drug excreted in urine for 48 hours. We did not find any significant differences in their bioavailabilities and that they should be clinically equally effective