Pseudo-Hypo-Parathyroidism [PHP] and Albright's Hereditary Osteodystrophy[AHO], review and two case reports

ABSTRACT

Pseudo-hypo-parathyroidism and Albright's hereditary osteodystrophy are rare but important diseases as they represent the only human disease states in which G protein function is disrupted. Decreased function of Gs alpha of adenylate cyclase results in receptor resistance to not only to PTH but to some other hormones as well. Case reports of two young females are reported. One had PHP-Ia along with a rare manifestation of the oligomenorrhea; while the other has PPHP with spinal cord compression, again a rare complication