TSH ultra-sensible et test a la TRH dans l'insuffisance ante-hypophysaire

ABSTRACT

In 74 patients with untreated pituitary insufficiency, the TRH- test [Ultra- Sensible TSH performed by immunoradiometric assay] has permitted to detect 48 thyreotrop deficiency. There is no correlation between basal TSH- us values and TSH reponse [TSH] under TRH; only 4 patients with pituitary hypothyroidism presented low basal TSH- us [<0.26 micro Ul/ml]. In the pituitary pathology, the TSH reponse under TRH remains indispensable for the evaluation of TSH pituitary reserves, since basal TSH- us value doesn't permit to predict the reponse TSH to TRH