Effect of chlordane form on fetal development in rats

ABSTRACT

Oral administration of chlordimeform in a dose of 1.0 ml/kg b. wt. during the period of organogenesis [6th - 15th days of gestation] significantly decreased the fetal body weight and resulted in hyperplasia in heart and liver in 6 and 8% of feti of rats, respectively. It caused corrugation of some ribs and absence of sessamoid bones of fore and hind-limbs of feti. The acricide in doses of 8.5 and 17.0 mg/kg b. wt. caused early resorption of 90 and 100% of embryos. Chlordimeform significantly decreased the number of corpus leutum and implantation sites