Hormonal assay in cases of primary atrophic rhinitis

ABSTRACT

This study was conducted on 40 cases of primary atrophic rhinitis in comparison with 10 normal control and 10 contact persons. A nasal biopsy had taken aiming to verify the clinical diagnosis and to localize the prostaglandin in this condition using PAP technique in comparison with normal control persons. In this study we found high plasma level of prostaglandin, A.C.T.H and cortisone. But less localization of prostaglandin in the nasal tissue in cases of primary atrophic rhinitis in comparison with normal control persons. This low localization of prostaglandin is due to the unhealthy endothelial cells of the blood vessels that normally synthetize the prostaglandin. The high plasma level of prostaglandin can be explained by the production of prostaglandin from other healthy tissues that triggered by the necrosis. This hight plasma level of prostaglandin results in high level of plasma. A.C.T.H and consequently plasma cortisone. The high level of plasma cortisone may exert inhibitory effect on many immune functions that lowers the local nasal tissue immunity leading to the chronicity of this condition