investigation of the possible mechanism for propranolol induced sexual dysfunction

ABSTRACT

Propranolol as a beta adrenergic blocking agent is widely used in therapeutics for many indications. The drug has been observed to produce sexual dysfunction in many patients. However, the mechanisms of this effect is still unclarified. The present work is designed to investigate the effect of subchronic administration of propranolol on rat testicular tissues and serum testosterone level. Propranolol was given in 3-dose levels for 4 weeks. Results revealed that propranolol could produce degenerative changes in the interstitial cells of Leydig as well as the sperm cells and this associated with significant reduction in serum testosterone level. These changes may be the cause of sexual dysfunction that complicate propranolol therapy. The possible mechanisms underlying these changes were discussed