Auto-antibodies in Toxanemic pregnancy

ABSTRACT

The total immunoglobulins levels IgG, IgM, IgA and IgE and some autoantibodies namely antiunclear [AN], antismooth muscle [ASM] and Anticardiolipin [ACL] antibodies were assayed in 26 patients with mild preeclamptic toxaemia [PET] and 21 patients with severe PET and 25 normotensive pregnant females. Concentration of IgG, IgM and IgA was slightly decreased in mild and severe PET, whereas in normal pregnancy, it showed no change. Concentration of IgE was higher in mild and sever PET than in control group. All cases of mild PET and control group were negative as regards ANA detection and only one case of severe PET group was positive [4.8%]. The level of ASMA and ACLA was significantly high in mild and severe PET groups. There was a significant relationship between the presence of ASMA and ACLA in maternal serum and the following the severity of preeclampisa, the presence of heavy proteinuria and the presence of subjective symptoms indicating emminent eclampsia