Manufacture and physical characteristics of directly compressed tablets of different types of L-ascorbic acid

ABSTRACT

Four types of L-Ascorbic Acid were compressed into tablets applying two formulae under different pressures. The prepared tablets were examined for their physical characteristics. It was found that [C-97] type produced by Takeda Chemical Industries LTD. Osaka/Tokyo and prepared by fluidized bed granulator to contain 3 per cent starch to be the best, as the tablets acquired good uniformity of weight and thickness, high hardness, low friability and disintegrated within the U.S.P. XX limit. Other types of L-Ascorbic Acid produced tablets with bad mechanical properties regarding low hardness and high friability and that prepared by silicone coated type did not conform to the U.S.P. and X requirement for disintegration