Influence of microcapsule size on the bioavailability of acetylsalicylic acid
Journal of Drug Research of Egypt. 1983; 14 (1-2): 211-218
em Inglês
| IMEMR
| ID: emr-3258
ABSTRACT
Preparation of ethylcellulose microcapsules containing ASA were achieved. Four microcapsule sizes were separated using standard sieves set. The percent release as well as the bioavailability of each size were studied to get a correlation between in-vitro and in-vivo drug availability. Larger size microcapsules were found to show a lower bio-availability when compared with smaller ones. The same was observed in-vitro. A good correlation between in-vitro and in-vivo data was noticed in testing the dissolution rate of microcapsules alter 15 and 30 min. with percent excretion of ASA after one hour
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Cápsulas
/
Disponibilidade Biológica
/
Química Farmacêutica
Idioma:
Inglês
Revista:
J. Drug Res. Egypt
Ano de publicação:
1983
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