Koilocytic lesions of the cervix and their relationship to CIN carcinoma cervix

ABSTRACT

303 uterine cervices, obtained from hysterectomy specimen were studied histologicaly. Various pathalogical conditions were categorized into non-dysplastic lesions [47.85%], mild dysplasia [CIN 1,29%], moderate dysplasia [CIN II, 7.9%], severe dysplasia [CIN 111,4.6%], and invasive carcioma [9.9%]. The issue sections were also assessed for the presence of koilocytes in the lesions mentioned, or in the surrounding epithelial cells Kailocytes were found in 69/303 cases [22.7%] and were divided into two groups Type A is more significantly related to Humman papilloma Virus infection and found in 27/69 [39.13%], while type B is less specific and was found in 42/69 [60.86%]. The association with other pathological lesions were studied, koilocytes A was found in 11/145 [8. 27%] of the non- dysplastic lesions, while it was seen in 8/88 [9.09%] of CIN 1,4/24[16.66%] of CIN 11, and 2/14 [14.28%] of CIN III and 1/30 [3.33%] of invasive carcinoma. The low incidence of HPV as evidenced by koilocytic changes in our patients might suggests a low incidence of invasive carcinom of the cervix in our community. More studies are needed to confirm this etiological relationship in our patients to identify the probable different factors that may operate in the causation of CIN and carcinoma together