Effects of superoxide dismutase on isoprenaline-induced damage to rat myocardium

ABSTRACT

This study was designed to investigate the effects of the enzyme superoxide dismutase [SOD] on isoprenaline- induced damage to rat myocardium. Four groups of rats were used. One group received isoprenaline [ISO] alone, another group received SOD alone, the third group with both ISO and SOD, the last group served as a control. Results have shown that SOD attenuated the biochemical and histopathological chances induced by ISO on myocardium; mainly by reducing the depletion of adenosine triphosphate [ATP] and glycogen, and reducing the serum malondialdehyde [MDA] level. It is concluded from this study that the enzyme SOD could play an important role in reducing myocardial damage associated with isehaemia