Down-modulation of the pathological profile in schistosomiasis hematobium by passive transfer of parasite-related idiotypic antibodies from infected children

ABSTRACT

Schistosoma haematobium adult worm related and egg [SEA] antigens were prepared and used to immunopurify specific antibodies from sera of infected children. The evaluation of the immunopurified NP-40 and SEA-related antibodies [idiotypes] for their ability to passively protect naive mice against S .haematobium infection were studied. Careful postmortem examination, as well as hepatic and pulmonary histopathological changes were carried out to evaluate the reduction in the degenerative changes in these organs after recovery from immune antibody recipients as compared with organs from infected groups given saline or normal human immunoglobulins-Analysis of results showed that idiotypes separated from sera of infected children are effective in minimizing pathological changes in the lungs and livers of mice which provides a tool for understanding the mechanism underlying idiotype mediated resistance to infection