Changes in lipid and lipoprotein values during a cross-over treatment of doxazosin, moduretic and amlodipine in hypertensive patients
JPMA-Journal of Pakistan Medical Association. 1994; 44 (7): 166-169
em Inglês
| IMEMR
| ID: emr-33111
ABSTRACT
A cross-over study, comparing the effects of doxazosin, moduretic and amlodipine on plasma lipid and lipoprotein levels in 9 hypertensive Nigerians aged 35 to 65 years is presented. Doxazosin therapy had favourable lipid changes characterized by a statistically significant reduction in total cholesterol [TC] at 6 months. Though consistent reduction was observed in total triglycerides [TG] low density lipoprotein cholesterol [LDL-C], very low density lipoprotein-cholesterol [VLDLC] upto 6 months, no effect was seen on high density lipoprotein cholesterol [HDLC]. This is against unfavourable increments in the mean values of TC, VLDLC, LDLC/HDLC and decrease in HDLC/TC during moduretic treatment phase. Amlodipine therapy did not alter the lipid and lipoprotein levels. The non-significant variation in the mean high density lipoprotein-cholesterol [HDLC] level observed with these agents, seem to suggest that HDL-cholesterol metabolism may be maintained during antihypertensive pharmacotherapy
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Colesterol
/
Lipídeos
/
Lipoproteínas
Limite:
Humanos
Idioma:
Inglês
Revista:
J. Pak. Med. Assoc.
Ano de publicação:
1994
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