Formulation and stability of atropine sulfate eye drops

Atropine sulfate was formulated in ophthalmic solutions using methylcellulose, sodium carboxymethylcellulose, polyvinyl alcohol, polyethylene glycol 6000, and polyvinyl-pyrrolidone K25. The formulations were subjected to stability studies. The obtained results revealed that, no degradation or complexion occur among the tested preparations with the exception of that contained methylcellulose. A significant decrease of drug content and viscosity of the solution was appeared after storage for the first month. Furthermore, the degradation in drug concentration was reached more than 60% after storage at 70C for two years. Also, TLC revealed a chemical decomposition of atropine sulfate in methylcellulose solution