Impaired fibrinolysis: another risk for hypertensives

ABSTRACT

The study comprised 30 hypertensive normoglycemic female patients subdivided into 2 groups according to body mass index [BMI]. Group 1, 15 hypertensive obese females with a BMI above 30 kg/m2. Group 2, 15 non obese hypertensive females with a BMI below 30 kg/m2. The groups were compared to 10 normotensive control subjects. They were subjected to detailed history taking and full clinical examination. Some anthropometric measures including weights and BMI were taken. Finally, they were subjected to laboratory investigations including determination of serum cholesterol, triglycerides and plasma plasminogen activator inhibitor-1. The results concluded a statistically significant elevation of serum cholesterol, triglycerides and plasminogen activator inhibitor-1, in both the obese and non obese hypertensive female patients in comparison with the normal control subjects. Also, there was positive correlation coefficient between PAI-1, cholesterol and TG in both obese and non obese patients. It is suggested that, control of elevated cholesterol, triglycerides, PAI through a diet regimen or otherwise is as important as the control of elevated blood pressure itself