Evaluation of different bleaching agents in the treatment of some hypermelanotic disorders

ABSTRACT

The study comprised 47 patients, 32 patients having melasma and 15 having Berloque dermatitis. The three bleaching agents were Kilgman Willis formula, hydrocortisone butyrate 0.1% oint. and hydroquinone 5% +retinoic acid 0.1% oint. applied twice daily except hydrocortisone butyrate 0.1% which was used once daily. These bleaching agents were applied for about 6 weeks. The response to these agents was detected by comparing the intensity of hypopigmentation after treatment and the presence of any side effect Zinc oxide oint. was applied in the morning as a sun screen. Hydrocortisone butyrate 0.1% was found more effective in the treatment of Berloque dermatitis than melasma [rhoc 0.05]. Kligman Willis formula and the combination of hydroquinone 5% +Retinoic acid 0.1% were more effective than hydrocortisone butyrate in the treatment of melasma. Erythema and peeling were marked with hydroquinon 5% +retinoic acid 0.1%