Insulin resistance in uremia

ABSTRACT

In chronic renal failure the abnormal carbohydrate metabolism is characterized by normal or slightly elevated fasting plasma glucose level, significantly increased plasma glucose concentration following glucose administration, hyperinsulinemia and insulin resistance. The present study was conducted on 20 uremic patients, 10 of them were under hemodialysis and 10 were not. 10 normal individuals served as control subjects. For each the following was done Blood urea and serum creatinine, creatinine clearance, oral glucose-insulin tolerance test extended for 2 hours serum K+ during OGTT. From the analysis of data obtained by the study, it was concluded that there was a significant state of insulin resistance which was manifested by significant increase in the blood glucose samples following glucose administration with simultaneously elevated plasma insulin level in all samples. There was no significant difference in the state of insulin resistance as regard the progress of renal failure, this was shown by the findings of nonsignificant differences in the indices that measure insulin resistance among patients under dialysis and those who are not. There was no significant improvement of the state of insulin resistance after dialysis