Morphologic effects of actinomycin D on the developing primary lymphoid tissues [Thymus gland and bursa of fabricius [BF]] of the chick embryos

ABSTRACT

Morphological and histological studies were made on the thymus gland and the thymus equivalent [BF] of the chick embryos injected in ova with actinomycin D [0.5 microgram/embryo] on the 10th day of incubation. It was found that actinomycin D caused morphological and histological changes in the thymus gland of 15-day old chick embryo in the form of less invaginated capsule with torn swollen dilated septa. Density of cells seemed to be more with increased vascularity. The changes in thymus equivalent, bursa of fabricius [BF] was in the form of more dilated cavity of the bursa, more lymphoid cells, as well as tears in the epithelial plates