Capillary permeability in patients with cardiac ischemia

ABSTRACT

74 patients with varying degree of ischaemic heart disease and 41 normal control subjects were studied for determining their capillary permeability. They were examined by various clinical and laboratory means. Assessment of their capillary permeability was performed by measuring the rate of disappearance of intravenously injected RISA from the circulation, Also digital tip blood flow and pulse wave velocity were measured for most of the members of both groups. Various associated diseases and complications of ischaemic heart disease were found in 82.4 percent of the patients. Capillary permeability was decreased in all patients with ischaemic heart disease except for those having associated C.O.P.D., diabetes, and hypertension in whom normal capillary permeability was found and was increased in cases of associated C.O.P.D. complicated with cardiac failure in whom the capillary permeability was increased above normal. The finger tip blood flow and pulse wave velocity were increased in all groups of ischaemic heart disease. The possible factors contributing to the decreased capillary permeability and its relation to increased digital blood flow and pulse wave velocity have been discussed. The decreased capillary permeability and hardening of the aorta - as shown by increased pulse wave velocity-tin cases of ischaemic heart disease add to whatever difficulty these patient might suffer from as a complication of their disease