On the teratogenic potential of zomepirac sodium

ABSTRACT

Zomepirac sodium, administered to pregnant rats did not cause any morphological abnormalities in transplacentally exposed embryos. It caused an inhibition of ossification of sternebral, specially the 5th and 6th, in as much as 30 percent of the treated embryos. Still birth, death, and sternebral malformation occurred under high dose treatments. However their frequencies did not reach statistical significance above those of the controls