Effect of oral bromocriptine parlodel on the endometrium of the adult female albino rat I A light microscopic study

The response of the endometrium to oral bromocriptine administration in low and high doses for 30 days and the effect of the drug withdrawal, 15 days after the last dose, was studied in adult albino rat. Both doses increased the thickness of the endometrial epithelial lining due to focal transformation into the pseudostratified columnar or even the stratified columnar types. However, the latter type was seen only in high dose-given animals. Bromocriptine administration in its low and high doses markedly increased the size of the stromal cell which contained abnormally abundant cytoplasm and oval around vesicular nuclei. These cells were separated by markedly increased collagen fiber. This was accompanied by the presence of large numbers of eosinophilis deep in the stroma. The drug increased markedly the cytoplasmic RNA content and lowered the DNA density in all endometrial cellular elements. Very highly satistical significant increase in the overall endome trial thickness occurred in response to bromocriptine administration. 15 days after the last bromocriptine dose, the endometrium regained its more less normal structure