Study of IV tenoxicam for analgesia after major orthopedic surgery

ABSTRACT

A controlled double blind study after major orthopedic surgery was done to compare a single I. V. dose of tenoxicam [20 mg] with placebo in 78 patients. It was associated with a reduction in consumption of morphine as assessed by patient-controlled analgesia. The consumption of morphine in tenoxicam group when compared with placebo was significantly reduced by 57% during the first 12 hour [P <0.002] and nonsignificantly reduced by 19.9% during the next 12-24 hour after operation [P >0.05]. When tenoxicam used as a single I.V. dose [20 mg], it has no significant effect on blood loss, bleeding tendency, or platelet functions. The possible adverse effects on hematological and renal functions are not recorded in their results: