Salivary prostaglandin concentration in cases of depression

ABSTRACT

This study was performed on 75 male and female subjects, they were nearly of the same socioeconomic levels from Sharqia Governorate and their ages ranged from 19 to 63 years. They were classified into three main groups. Group 1 included 25 control subjects. They were healthy and completely free from any clinical psychiatric disturbances. Group 2 comprised 16 patients having neurotic depression. Group 3 involved 34 subjects having major depression. The results were statistically analyzed and data revealed that salivary prostaglandin E2 levels were significantly higher in major depression groups as compared to the control group and patients with neurotic depression. Also, with increasing severity of major depression which was more pronounced in severe major depression. There was significant difference between female and male depression patients. In contrast, salivary PGE2 levels showed no significant difference between neurotic depression group and control group, no significant difference between unipolar depression subgroup and bipolar depression subgroup and also no significant difference between melancholic and non melancholic depression subgroups