Relation of plasma 1,25 [OH] 2 D3 to clinical and biochemical parameters of renal rickets in Egyptian children

ABSTRACT

Thirty cases of refractory rickets were studied. They were classified according to their laboratory data into four groups renal osteodystrophy [R.O.D.], hypophosphatemic rickets, renal tubular acidosis [R.T.A.] and vitamin D dependent rickets [V.D.D.R.]. Plasma 1,25[0 H]2 D3, 1,25-dihydroxycholecalciferol, was estimated in all patients and in fifteen normal control children of the same age range. It was significantly reduced in R.O.D., hypophosphatemic rickets and [H.P.R.]. In the control group, it was significantly correlated to chronological age, serum calcium, phosphorus, alkaline phosphatase, and urinary phosphate. On the other hand, it was not significantly correlated to the biochemical parameters measured in the diseased groups