Influence of piroxicam and piroxicam-cyclodextrin inclusions on gastric mucosal ulceration: an experimental study

ABSTRACT

The study was performed to prove the ulcerogenic effect of piroxicam [as an example of NSAIDs] in stomachs of experimental animals and to evaluate the protective effect of inclusion complexation of piroxicam with beta-cyclodextrin [B-CyD] against gastric irritation. 15 Wistar rats were used in this study. The drugs were given orally for 4 consecutive days and the animals were sacrificed on the fifth day. Their stomachs were examined both macroscopically [by measurement of ulcer index, UI] and microscopically. The study documented the ulcerogenic effect of piroxicam both macroscopically and microscopically. Moreover, it proved the benefit of piroxicam beta- CyD complexation in reducing its gastric ulceration