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Influence of piroxicam and piroxicam-cyclodextrin inclusions on gastric mucosal ulceration: an experimental study
New Egyptian Journal of Medicine [The]. 1994; 11 (2): 1038-1041
em Inglês | IMEMR | ID: emr-34711
ABSTRACT
The study was performed to prove the ulcerogenic effect of piroxicam [as an example of NSAIDs] in stomachs of experimental animals and to evaluate the protective effect of inclusion complexation of piroxicam with beta-cyclodextrin [B-CyD] against gastric irritation. 15 Wistar rats were used in this study. The drugs were given orally for 4 consecutive days and the animals were sacrificed on the fifth day. Their stomachs were examined both macroscopically [by measurement of ulcer index, UI] and microscopically. The study documented the ulcerogenic effect of piroxicam both macroscopically and microscopically. Moreover, it proved the benefit of piroxicam beta- CyD complexation in reducing its gastric ulceration
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Índice: IMEMR (Mediterrâneo Oriental) Assunto principal: Neoplasias da Glândula Tireoide / Complemento C3c / Doença de Graves Idioma: Inglês Revista: New Egypt. J. Med. Ano de publicação: 1994

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Índice: IMEMR (Mediterrâneo Oriental) Assunto principal: Neoplasias da Glândula Tireoide / Complemento C3c / Doença de Graves Idioma: Inglês Revista: New Egypt. J. Med. Ano de publicação: 1994