Teratogenic potential of Adriamycin, cytophotometric analysis

ABSTRACT

The present study investigated by cytophotometric analysis the teratogenic effect of adriamycin on oral tissues of albino rats. The offsprings of adriamycin injected female rats were divided into two groups, each comprising 10 rats sacrificed at one month and 3 months of age. The tongue of each sacrificed animals was dissected and prepared for cytophotometric measurements. The results of the present investigation revealed a significant difference in the nuclear DNA distribution pattern in the experimental and the control populations in the first and third month specimens denoting a change in DNA metabolism in rats born to adriamycin-injected mothers. It could be concluded that, adriamycin administration could alter the pattern of DNA cells and metabolism in the oral mucosal cells. The basic DNA deviation could be a latent effect, or might affect the genetic composition of the offsprings which would pass to the following generations. The potential risk of teratoaenesis is great, especially if early trimester treatments are necessary