Role of some interleukins in atopic dermatitis

ABSTRACT

This study was done on 40 atopic dermatitis patients, 22 males and 18 females, positive family history was present in 42.5% of cases and personal history in 12.5% of them. Fifteen of the patients were of the infantile type [37.5%] while 9 were of the Besniers prurigo [22.5%] and 16 of the atypical childhood type [40%]. According to the clinical severity, they were classified into severe [n = 10], moderate [n = 25] and mild [n = 5] [following Rajka, 1990]. According to their IgE level, they were classified into two groups Highly atopics [IgE >600 mu/ml] and atopics [IgE <600 mu/ml]. The patients were compared with 20 non atopic control, of the same age. From each person of the study group, a serum samples were taken and examined by ELISA technique for serum IgG level. A heparinized samples were taken, from which peripheral blood mononuclear cell [PBMNC] cultures were prepared and supernatant were examined for the level of inteleukin 4 [IL 4] and [IL 6] by ELISA technique. From the present study it was concluded that, IL 4 plays an important role in atopic dermatitis being produced in excess in PBMNc cultures in all groups of the disease, especially in the severe and highly atopic groups