Sustained release verpamil in hypertensive patients

ABSTRACT

Thirty patients [22 females and 8 males] were put on Verapamil SR, a slow release calcium channel blocker, for three weeks on out door basis. Mean age was 44.3 +/- 2.5 years, mean weight before treatment was 67.1 +/- 24 Kg, after treatment it was 64.7 +/- 3.5 Kg, mean height was 156 +/- 3 Cm and mean duration of hypertension was 3.89 +/- 1.5 Years. Mean supine systolic pressure decreased from 164 +/- 2.33 mmHg to 140 +/- 6.5 mmHg [P<0.01] while supine standing pressure decreased from 163.6 +/- 4.1 mmHg to 147.5 +/- 04 mmHg [p<0.01]. Fall in mean supine diastolic pressure was from 107.33 +/- 1.14 mmHg to 91 +/- 4.2 mmHg [P<0.01] while fall in standing diastolic pressure was from 110 +/- l.7 mmHg to 97.3 +/- 2.1 mmHg [p<0.001]. Mean supine arterial pressure decreased from 126 mmHg to 107.3 mmHg while standing mean arterial pressure decreased from 127.9 mmHg to 114 mmHg. No statistically significant fall in heart rate both in supine and standing position was observed. laboratory results did not show any variation. In 72% of the patients supine systolic pressure was patients supine diastolic pressure was Verapamil SR was found moderately effective and safe in controlling mild to moderate hypertension