comparative evaluation of Sch 25298 a fluorinated derivative of chloramphenicol

ABSTRACT

To determine the in vitro activity of Sch 25298, a fluorinated derivative of chloramphenicol. Determinations of minimum inhibitory concentration by agar dilution method of Sch 25298 and chloramphenicol against 922 recent clinical isolates. King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. Sch 25298 was more inhibitory than chloramphenicol against both methicillin-susceptible and methicillin resistant Staphylococcus aureus, coagulase negative staphylococci, enterococci, Haemophilus influenzae and members of Enterobacteriaceae. Its antibacterial activity against streptococci was comparable with that of chloramphenicol. All the 89 isolates of Pseudomonas aeruginosa and Acinetobacter were resistant to both Sch 25298 and chloramphenicol. Sch 25298 exhibited more potent antibacterial activity than chloramphenicol against most of the bacteria tested. Many of the chloramphenicol-resistant isolates were susceptible to Sch 25298