Role of enalapril maleate in controlling hypertension: a clinical study

ABSTRACT

Enalapril maleate, an angiotensin converting enzyme inhibitor, was given to patients suffering from mild to moderate hypertension to observe its antihypertensive effect. Twenty hypertensive patients were put on enalapril maleate 5mg to 40mg daily for four months after discontinuing previous antihypertensive therapy for six weeks. Sitting systolic blood pressure decreased from 163.3 +/- 2.9 mmHg to 143.6 +/- 5.4 mmHg while sitting diastolic pressure decreased from 106 +/- 1.3 mmHg to 89.5 +/- 1.9 mmHg. Standing systolic blood pressure decreased from 165.9 +/- 3.5 mmHg to 145.7 +/- 4.7 mmHg while standing diastolic blood pressure decreased from 108.5 +/- 1.1 mmHg to 92.8 +/- 1.8 mmHg. There was no change in pulse rate both in sitting and standing position. Only one patient showed hypersensitivity reaction. Blood pressure control was satisfactory in 14 patients. Enalapril Maleate was found effective in decreasing blood pressure in patients with mild to moderate hypertension