Spectrophotometric determination of paracetamol, Salicylamide and codeine phosphate in mixture

ABSTRACT

A spectrophotometric method for the analysis of a mixture of paracetamol, salicylamide and codeine phosphate is described. Paracetamol is determined by measuring its absorbance at lambdamax247 nm after separation from salicylamide and codeine phosphate at pH 8 by solvent extraction. The other two components were separated through the acid-dye method, where codeine phosphate forms an ion-pair complex with thymol blue at pH3 [lambdamax247 nm]. While salicylamide doesnot form such complex and can be estimated; without interference; at lambdamax307nm.beer-Lambert law was adhered to over the range of 2-14,4-24, and 5-30 micro g/ml for paracetamol, salicylamide and codeine phosphate respectively. This method was successfully applied for the analysis of laboratory synthetic mixture and also for pharmaceutical dosage from containing this ternary mixture