Hepatites medicamenteuses a la methyldopa: a propos de 3 cas
Tunisie Medicale [La]. 1994; 72 (1): 47-50
em Francês
| IMEMR
| ID: emr-35739
ABSTRACT
Between January 1991 and Janury 1992, we have collected in National Center of Pharmacovigilance, 3 cases of drug-induced hepatitis in which the responsability of Methyldopa was suspected. In 2 cases, we noticed a mixed hepatitis that associate an intense cytolysis, a cholestase and a hepatocellular insufficiency. Cytolysis, cholestase and hepatoceliular insufficiency evolved favouraby after stopping treatment in all cases. The great delay from treatment start [4 months to 5 years] and the previous hepatitis history in all cases, suggested a toxi mechanism for these drug-induced hepatitis. As Mehtyldopa is still used in many countries for its cheaper cost, we must take care before prescribing it by a good research of hepatic antecedents
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Hepatite
/
Fígado
/
Metildopa
Tipo de estudo:
Relato de Casos
Limite:
Feminino
/
Humanos
Idioma:
Francês
Revista:
Tunisie Med.
Ano de publicação:
1994
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