Nifedipine versus isradipine as antiatherogenic modalities in cholesterol fed rabbits
Zagazig Medical Association Journal. 1994; 7 (1): 83-96
em Inglês
| IMEMR
| ID: emr-35934
ABSTRACT
The antiatherogenic effect of nifedipine and isradipine was experimentally studied in cholesterol fed-rabbits. Our results demonstrate that isradipine in therapeutic doses relevant to human use, has antiatherogenic activity in cholesterol-fed rabbit model. On the other hand nifedipine has a comparable effect but at doses that are much higher than equivalent human doses. Furthermore isradipine significantly increased [P 0.05], while nifedipine insignificantly decreased high density lipoprotein-cholesterol [HDL] level than in the non-atherosclerotic control group of rabbits. We concluded that isradipine, and not nifedipine. is an effective and applicable antiatherogenic modality in proper clinical setting:
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Nifedipino
/
Isradipino
/
Aterosclerose
/
Hiperlipidemias
/
Lipoproteínas HDL
/
Infarto do Miocárdio
Limite:
Animais
Idioma:
Inglês
Revista:
Zagazig Med. Assoc. J.
Ano de publicação:
1994
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