Nifedipine versus isradipine as antiatherogenic modalities in cholesterol fed rabbits

ABSTRACT

The antiatherogenic effect of nifedipine and isradipine was experimentally studied in cholesterol fed-rabbits. Our results demonstrate that isradipine in therapeutic doses relevant to human use, has antiatherogenic activity in cholesterol-fed rabbit model. On the other hand nifedipine has a comparable effect but at doses that are much higher than equivalent human doses. Furthermore isradipine significantly increased [P 0.05], while nifedipine insignificantly decreased high density lipoprotein-cholesterol [HDL] level than in the non-atherosclerotic control group of rabbits. We concluded that isradipine, and not nifedipine. is an effective and applicable antiatherogenic modality in proper clinical setting: